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KMID : 0370019990130000023
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Chung-Ang Journal of Pharmacal Sciences
1999 Volume.13 No. 0 p.23 ~ p.31
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Phenolic compounds from leaves of Weigela florida var glabra
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Abstract
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The constituent of the leaves of Weigela florida var. glabra Caprifoliaceae were studied phytochemically in order to investigate any resources of them, because the leaves of Weigela florida var. glabra has not been studied as medicinal plant.
The methanolic extract of them was suspended with water and then partitioned with ethyl ether. The aqueous fraction was submitted to column chromatography on Diaion HP-20 with gradient solvent system as follows; 100% H_2O, 20% MeOH, 60% MeOH, 100% MeOH.
20% MeOH and 60% MeOH fraction were subjected to sephadex LH-20 column chromatography using 15%, 50% MeOH to yield compound Ⅰ, Ⅱ, Ⅲ and Ⅳ.
Structures of the four compounds were elucidated by spectroscopic parameters of ^1H-NMR, ^13C-NMR, DT-IR and FAB-MS, and identified as; Compound Ⅰ(Fraxetin), Compound Ⅱ (FRaxin-β-D-glucopyranoside), Compound Ⅲ(Quercetin), and Compound Ⅳ (Quercetin-3-O-β-D-glucopyranosyl(1→2)-β-D-glucopyranoside).
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